ova 257-264 peptide OVA (257-264 - OVASIINFEKL OVA Peptide Understanding the OVA 257-264 Peptide: A Key Player in Immune Response Research

OVASIINFEKL The OVA 257-264 peptide, also known by its sequence SIINFEKL, is a significant and well-characterized octameric peptide derived from ovalbumin (OVA), the primary protein found in egg whites. This peptide holds particular importance in immunology and biomedical research due to its role as a class I (Kb)-restricted peptide epitope of OVA.OVA (257-264), FAM labeled - 1 mg This means it is specifically recognized and presented by the class I MHC molecule, H-2Kb, on the surface of cells, thereby initiating an immune response.

The scientific community frequently utilizes the OVA 257-264 peptide in various research applications. Its precise structure and predictable interaction with the H-2Kb MHC molecule make it an invaluable tool for studying T cell responses. For instance, it is used to stimulate T cells in PBMCs (Peripheral Blood Mononuclear Cells), allowing researchers to quantify peptide epitope specificity and measure the release of effector cells like IFN-γ through assays such as ELISPOT. This capability is crucial for understanding cellular immunity and developing potential therapeutic strategies.Ovalbumin-derived peptideknown to arise from a natural processing of ovalbumin H-2b mouse cells. Subcutaneous immunization with this peptide could induce OVA- ...

Furthermore, the OVA 257-264 peptide is recognized as an immunodominant epitope derived from chicken ovalbumin protein (UniProt P01012). Its consistent presentation by MHC class I molecules makes it a reliable model antigen for investigating immune system functions. Researchers often employ this peptide in studies focusing on T-cell activation and the development of immune tolerance or sensitizationOVA 257-264 is a class I (Kb)-restricted peptide epitopeof the ovalbumin protein, presented by the class I major histocompatibility complex (MHC) molecule, H- .... The OVA protein itself serves as a common antigen in many immunological experiments, and the OVA 257-264 peptide represents a specific, highly immunogenic fragment of this larger protein.

The chemical formula for the Ova peptide (257-264) is C45H74N10O13, as detailed in resources like PubChem. This precise molecular composition underscores its nature as a defined chemical entity.OVA Peptide (257-264)_索莱宝|主营生物科研试剂&抗体|蛋白 In scientific literature and product listings, you will frequently encounter it referred to as OVA (257-264), OVA 257-264 (SIINFEKL), or simply SIINFEKL peptide. Variations also exist, such as the OVA 257-264 peptide TFA (trifluoroacetate salt), which is a common form for peptide synthesis and storage, ensuring stability and purityOVA Peptideis a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC molecule, H-2Kb..

The significance of OVA peptide (257-264) extends to its role in developing vaccines and understanding autoimmune responses. For example, the concept of a "DC-OVA vaccine" or vaccinations incorporating OVA 257-264 is a class I (Kb)-restricted peptide epitope of OVA are explored in the context of cancer immunotherapy and allergy research. The ability of this peptide to trigger specific immune responses makes it a target for modulation in these fields.

In summary, the OVA 257-264 peptide is a fundamental component in immunological research. Its well-defined structure, its role as a class I (Kb)-restricted peptide epitope of OVA, and its presentation by the H-2Kb MHC molecule make it indispensable for studying cellular immunity, T cell activation, and the development of novel immunotherapies. Whether referred to as OVA peptide, Ovalbumin (257-264) chicken, or by its amino acid sequence SIINFEKL, this ovalbumin-derived peptide continues to be a cornerstone in advancing our understanding of the immune system.OVA 257 264 peptide (SIINFEKL)– CAS: 138831-86-4